Epigenetic age acceleration and metabolic syndrome in the coronary artery risk development in young adults study.

ABSTRACT:

Background

The metabolic syndrome (MetS) is a collection of metabolic disturbances that can lead to various cardiovascular diseases. Previous studies have shown a more adverse metabolic risk profile is associated with more advanced biological aging. The associations between epigenetic biomarkers of age with MetS, however, are not well understood. We therefore investigated the associations between epigenetic age acceleration and MetS severity score and incident MetS.

Results

A subset of study participants with available whole blood at examination years 15 and 20 from the Coronary Artery Risk Development in Young Adults Study underwent epigenomic profiling using the Illumina MethylationEPIC Beadchip (~ 850,000 sites). Intrinsic and extrinsic epigenetic age acceleration (IEAA a

SUBMITTER: Nannini DR 

PROVIDER: S-EPMC6858654 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature