A panel of Transcription factors identified by data mining can predict the prognosis of head and neck squamous cell carcinoma.

ABSTRACT:

Background

Transcription factors (TFs) are responsible for the regulation of various activities related to cancer like cell proliferation, invasion, and migration. It is thought that, the measurement of TFs levels could assist in developing strategies for diagnosis and prognosis of cancer detection. However, due to lack of effective genome-wide tests, this cannot be carried out in clinical settings.

Methods

A complete assessment of RNA-seq data in samples of a head and neck squamous cell carcinoma (HNSCC) cohort in The Cancer Genome Atlas (TCGA) database was carried out. From the expression data of six TFs, a risk score model was developed and further validated in the GSE41613 and GSE65858 series. Potential functional roles were identified for the six TFs via gene set enrich

SUBMITTER: Zhang B 

PROVIDER: S-EPMC6858662 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature