Composite lymphoma of concurrent T zone lymphoma and large cell B cell lymphoma in a dog.

ABSTRACT:

Background

Evolution of indolent to aggressive lymphoma has been described in dogs but is difficult to distinguish from the de novo development of a second, clonally distinct lymphoma. Differentiation of these scenarios can be aided by next generation sequencing (NGS)-based assessment of clonality of lymphocyte antigen receptor genes.

Case presentation

An 8-year-old male intact Mastiff presented with generalized lymphadenomegaly was diagnosed with nodal T zone lymphoma (TZL) based on cytology, histopathology, immunohistochemistry and flow cytometry. Thirteen months later, the dog re-presented with progressive lymphadenomegaly, and based on cytology and flow cytometry, a large B cell lymphoma (LBCL) was diagnosed. Sequencing-based clonality testing confirmed the de novo devel

SUBMITTER: Matsuyama A 

PROVIDER: S-EPMC6858704 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature