Locally instructed CXCR4^hi neutrophils trigger environment-driven allergic asthma through the release of neutrophil extracellular traps.

ABSTRACT: Low exposure to microbial products, respiratory viral infections and air pollution are major risk factors for allergic asthma, yet the mechanistic links between such conditions and host susceptibility to type 2 allergic disorders remain unclear. Through the use of single-cell RNA sequencing, we characterized lung neutrophils in mice exposed to a pro-allergic low dose of lipopolysaccharide (LPS) or a protective high dose of LPS before exposure to house dust mites. Unlike exposure to a high dose of LPS, exposure to a low dose of LPS instructed recruited neutrophils to upregulate their expression of the chemokine receptor CXCR4 and to release neutrophil extracellular traps. Low-dose LPS-induced neutrophils and neutrophil extracellular traps potentiated the uptake of house dust mites by CD11b<

SUBMITTER: Radermecker C 

PROVIDER: S-EPMC6859073 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature