Association Between Body Mass Index and All-Cause Death in Japanese Population: Pooled Individual Participant Data Analysis of 13 Cohort Studies.

ABSTRACT:

Background

We sought to investigate the optimal values of BMI for the lowest risk of all-cause death and whether the optimal BMI differs according to smoking status in large-scale pooled analysis of 13 Japanese cohorts.

Methods

Data from 179,987 participants of 13 well-qualified cohort studies conducted throughout Japan were used for our analysis. A cohort-stratified Cox proportional hazard model was used. P values for interactions were calculated based on the cross product of BMI and age, sex, or smoking status.

Results

In the entire study population, all-cause mortality risk was lowest when the BMI was 22.0-24.9 kg/m². This was also the case for selected healthy participants (never smoked, baseline total cholesterol level ≥4.1 mmol/L; the first 5 years of

SUBMITTER: Hozawa A 

PROVIDER: S-EPMC6859077 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature