Comparative analysis of differential proteome-wide protein-protein interaction network of Methanobrevibacter ruminantium M1.

ABSTRACT: A proteome-wide protein-protein interaction (PPI) network of Methanobrevibacter ruminantium M1 (MRU), a predominant rumen methanogen, was constructed from its metabolic genes using a gene neighborhood algorithm and then compared with closely related rumen methanogens Using proteome-wide PPI approach, we constructed network encompassed 2194 edges and 637 nodes interacting with 634 genes. Network quality and robustness of functional modules were assessed with gene ontology terms. A structure-function-metabolism mapping for each protein has been carried out with efforts to extract experimental PPI concomitant information from the literature. The results of our study revealed that some topological properties of its network were robust for sharing homologous protein interactions across h

SUBMITTER: M B 

PROVIDER: S-EPMC6859225 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature