Gene Expression Alterations in the Bronchial Epithelium of e-Cigarette Users.

ABSTRACT:

Background

Although e-cigarette (ECIG) use has increased in the United States, their potential health effects remain uncertain. Understanding the effects of tobacco cigarette (TCIG) smoke on bronchial airway epithelial gene expression have previously provided insights into tobacco-related disease pathogenesis. Identifying the impact of ECIGs on airway gene expression could provide insights into their potential long-term health effects. We sought to compare the bronchial airway gene-expression profiles of former TCIG smokers now using ECIGs with the profiles of former and current TCIG smokers.

Methods

We performed gene-expression profiling of bronchial epithelial cells collected from current TCIG smokers (n = 9), current ECIG users who are former TCIG smokers (n = 15), and fo

SUBMITTER: Corbett SE 

PROVIDER: S-EPMC6859252 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature