Pre-detection history of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa.

ABSTRACT: Antimicrobial-resistant (AMR) infections pose a major threat to global public health. Similar to other AMR pathogens, both historical and ongoing drug-resistant tuberculosis (TB) epidemics are characterized by transmission of a limited number of predominant Mycobacterium tuberculosis (Mtb) strains. Understanding how these predominant strains achieve sustained transmission, particularly during the critical period before they are detected via clinical or public health surveillance, can inform strategies for prevention and containment. In this study, we employ whole-genome sequence (WGS) data from TB clinical isolates collected in KwaZulu-Natal, South Africa to examine the pre-detection history of a successful strain of extensively drug-resistant (XDR) TB known as LAM4/KZN, firs

SUBMITTER: Brown TS 

PROVIDER: S-EPMC6859317 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature