Proteomics analysis of the amygdala in rats with CFA-induced pain aversion with electro-acupuncture stimulation.

ABSTRACT:

Background

Clinical patients suffering from pain usually exhibit aversion to pain-associated environments (pain aversion). Electro-acupuncture (EA) has been proven to be effective for the treatment of pain aversion in our previous studies. The amygdala could have substantial consequences on emotion and pain consolidation as well as general pain aversion behavior, however, the underlying mechanism remains unclear.

Purpose

The current study was performed to investigate Isobaric tags for relative and absolute quantitation (iTRAQ) based quantitative proteomic analysis of the amygdala in rats with complete Freund's adjuvant (CFA)-induced pain aversion, and comprehensive analysis of protein expression were performed to explore the underlying mechanism by which EA affects pain aver

SUBMITTER: Wu Y 

PROVIDER: S-EPMC6859335 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature