Membrane curvature underlies actin reorganization in response to nanoscale surface topography.

ABSTRACT: Surface topography profoundly influences cell adhesion, differentiation, and stem cell fate control. Numerous studies using a variety of materials demonstrate that nanoscale topographies change the intracellular organization of actin cytoskeleton and therefore a broad range of cellular dynamics in live cells. However, the underlying molecular mechanism is not well understood, leaving why actin cytoskeleton responds to topographical features unexplained and therefore preventing researchers from predicting optimal topographic features for desired cell behavior. Here we demonstrate that topography-induced membrane curvature plays a crucial role in modulating intracellular actin organization. By inducing precisely controlled membrane curvatures using engineered vertical nanostructures as topog

SUBMITTER: Lou HY 

PROVIDER: S-EPMC6859365 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature