Distinct Mechanisms for Visual and Motor-Related Astrocyte Responses in Mouse Visual Cortex.

ABSTRACT: Astrocytes are a major cell type in the mammalian nervous system, are in close proximity to neurons, and show rich Ca²⁺ activity thought to mediate cellular outputs. Astrocytes show activity linked to sensory [1, 2] and motor [3, 4] events, reflecting local neural activity and brain-wide neuromodulatory inputs. Sensory responses are highly variable [5-10], which may reflect interactions between distinct input types [6, 7, 9]. However, the diversity of inputs generating astrocyte activity, particularly during sensory stimulation and behavior, is not fully understood [11, 12]. Using a combination of Ca²⁺ imaging, a treadmill assay, and visual stimulation, we examined the properties of astrocyte activity in mouse visual cortex associated with motor or sensory events. Con

SUBMITTER: Slezak M 

PROVIDER: S-EPMC6859477 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature