HIF-1α protects against oxidative stress by directly targeting mitochondria.

ABSTRACT: The transcription factor hypoxia inducible factor-1α (HIF-1α) mediates adaptive responses to oxidative stress by nuclear translocation and regulation of gene expression. Mitochondrial changes are critical for the adaptive response to oxidative stress. However, the transcriptional and non-transcriptional mechanisms by which HIF-1α regulates mitochondria in response to oxidative stress are poorly understood. Here, we examined the subcellular localization of HIF-1α in human cells and identified a small fraction of HIF-1α that translocated to the mitochondria after exposure to hypoxia or H₂O₂ treatment. Moreover, the livers of mice with CCl₄-induced fibrosis showed a progressive increase in HIF-1α association with the mitochondria, indicating the clinical relev

SUBMITTER: Li HS 

PROVIDER: S-EPMC6859547 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature