Redox inhibition of protein phosphatase PP2A: Potential implications in oncogenesis and its progression.

ABSTRACT: Cellular processes are dictated by the active signaling of proteins relaying messages to regulate cell proliferation, apoptosis, signal transduction and cell communications. An intricate web of protein kinases and phosphatases are critical to the proper transmission of signals across such cascades. By governing 30-50% of all protein dephosphorylation in the cell, with prominent substrate proteins being key regulators of signaling cascades, the phosphatase PP2A has emerged as a celebrated player in various developmental and tumorigenic pathways, thereby posing as an attractive target for therapeutic intervention in various pathologies wherein its activity is deregulated. This review is mainly focused on refreshing our understanding of the structural and functional complexity that cocoons th

SUBMITTER: Raman D 

PROVIDER: S-EPMC6859563 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature