Thiol regulation by Mn porphyrins, commonly known as SOD mimics.

ABSTRACT: Superoxide dismutases play an important role in human health and disease. Three decades of effort have gone into synthesizing SOD mimics for clinical use. The result is the Mn porphyrins which have SOD-like activity. Several clinical trials are underway to test the efficacy of these compounds in patients, particularly as radioprotectors of normal tissue during cancer treatment. However, aqueous chemistry data indicate that the Mn porphyrins react equally well with multiple redox active species in cells including H₂O₂, O₂^•-, ONOO^-, thiols, and ascorbate among others. The redox potential of the Mn porphyrins is midway between the potentials for the oxidation and reduction of O₂^•-. This positions them to react equall

SUBMITTER: Batinic-Haberle I 

PROVIDER: S-EPMC6859569 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature