15-Keto prostaglandin E₂ suppresses STAT3 signaling and inhibits breast cancer cell growth and progression.

ABSTRACT: Overproduction of prostaglandin E₂ (PGE₂) has been linked to enhanced tumor cell proliferation, invasiveness and metastasis as well as resistance to apoptosis. 15-Keto prostaglandin E₂ (15-keto PGE₂), a product formed from 15-hydroxyprostaglandin dehydrogenase-catalyzed oxidation of PGE₂, has recently been shown to have anti-inflammatory and anticarcinogenic activities. In this study, we observed that 15-keto PGE₂ suppressed the phosphorylation, dimerization and nuclear translocation of signal transducer and activator of transcription 3 (STAT3) in human mammary epithelial cells transfected with H-ras (MCF10A-ras). 15-Keto PGE₂ inhibited the migration and clonogenicity of MCF10A-ras cells. In addition, subcutaneous

SUBMITTER: Lee EJ 

PROVIDER: S-EPMC6859578 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature