Epidemiological and Economic Effects of Priming With the Whole-Cell Bordetella pertussis Vaccine.

ABSTRACT:

Importance

Current acellular pertussis vaccines may not protect against transmission of Bordetella pertussis.

Objective

To assess whether a priming dose of whole-cell pertussis (wP) vaccine is cost-effective at reducing pertussis infection in infants.

Design, setting, and participants

Mathematical model of pertussis transmission fit to US incidence data in a simulation of the US population. In this simulation study conducted from June 2014 to May 2015, the population was divided into 9 age groups corresponding to the current pertussis vaccination schedule and fit to 2012 pertussis incidence.

Interventions

Inclusion of a priming dose of wP vaccine into the current acellular pertussis vaccination schedule.

Main outcomes and measures

Reductions in symptomat

SUBMITTER: DeAngelis H 

PROVIDER: S-EPMC6859645 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature