In Silico Tissue Engineering: A Coupled Agent-Based Finite Element Approach.

ABSTRACT: Over the past two decades, the increase in prevalence of cardiovascular diseases and the limited availability of autologous blood vessels and saphenous vein grafts have motivated the development of tissue-engineered vascular grafts (TEVGs). However, compliance mismatch and poor mechanical properties of the TEVGs remain as two major issues that need to be addressed. Researchers have investigated the role of various culture conditions and mechanical conditioning in deposition and orientation of collagen fibers, which are the key structural components in the vascular wall; however, the intrinsic complexity of mechanobiological interactions demands implementing new engineering approaches that allow researchers to investigate various scenarios more efficiently. In this study, we utilized a coup

SUBMITTER: Keshavarzian M 

PROVIDER: S-EPMC6859697 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature