Helicobacter pylori Infection Aggravates Dysbiosis of Gut Microbiome in Children With Gastritis.

ABSTRACT: Introduction: Helicobacter pylori infection consistently leads to chronic and low degree of inflammatory response in gastric mucosa and is closely related with gastrointestinal and extra-gastric diseases. Effects of local microbiome in the stomach have been studied in adults and children with H. pylori infection. It is, however, not known whether the intestinal microbial community differs in children with varying H. pylori infection. The aim of this study is to characterize the altered composition of microbiome induced by H. pylori infection and in gastritis. Materials and Methods: This study involved 154 individuals, including 50 children affected by H. pylori-induced gastritis, 42 children with H. pylori-negative gastritis, and 62 healthy controls. Gut microbiome composition was analyzed

SUBMITTER: Yang L 

PROVIDER: S-EPMC6859803 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature