Quantifying the axonal pathways directly stimulated in therapeutic subcallosal cingulate deep brain stimulation.

ABSTRACT: Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) is an emerging experimental therapy for treatment-resistant depression. New developments in SCC DBS surgical targeting are focused on identifying specific axonal pathways for stimulation that are estimated from patient-specific computational models. This connectomic-based biophysical modeling strategy has proven successful in improving the clinical response to SCC DBS therapy, but the DBS models used to date have been relatively simplistic, limiting the precision of the pathway activation estimates. Therefore, we used the most detailed patient-specific foundation for DBS modeling currently available (i.e., field-cable modeling) to evaluate SCC DBS in our most recent cohort of six subjects, all of which were responders to the t

SUBMITTER: Howell B 

PROVIDER: S-EPMC6859839 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature