Noninvasive Serum Fibrosis Markers are Associated with Coronary Artery Calcification in Patients with Nonalcoholic Fatty Liver Disease.

ABSTRACT:

Background/aims

Advanced hepatic fibrosis is associated with cardiovascular disease (CVD) in patients with nonalcoholic fatty liver disease (NAFLD). We investigated the association between noninvasive serum fibrosis markers and the coronary artery calcium score (CACS) in subjects with NAFLD.

Methods

We analyzed 665 NAFLD subjects without chronic liver disease or heart disease between 2011 and 2015. The noninvasive fibrosis markers that were used to evaluate the severity of hepatic fibrosis included the NAFLD fibrosis score (NFS), fibrosis-4 (FIB-4) score, Forn's index, and the aspartate aminotransferase to platelet ratio index (APRI).

Results

The areas under the receiver operating characteristics curves for the NFS, FIB-4 score, Forn's index and APRI for predicting CA

SUBMITTER: Song DS 

PROVIDER: S-EPMC6860032 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature