A mechanistic integrative computational model of macrophage polarization: Implications in human pathophysiology.

ABSTRACT: Macrophages respond to signals in the microenvironment by changing their functional phenotypes, a process known as polarization. Depending on the context, they acquire different patterns of transcriptional activation, cytokine expression and cellular metabolism which collectively constitute a continuous spectrum of phenotypes, of which the two extremes are denoted as classical (M1) and alternative (M2) activation. To quantitatively decode the underlying principles governing macrophage phenotypic polarization and thereby harness its therapeutic potential in human diseases, a systems-level approach is needed given the multitude of signaling pathways and intracellular regulation involved. Here we develop the first mechanism-based, multi-pathway computational model that describes the integrate

SUBMITTER: Zhao C 

PROVIDER: S-EPMC6860420 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature