Preference-based measure of health-related quality of life and its determinants in sickle cell disease in Nigeria.

ABSTRACT:

Background

Health-related quality of life (HRQL) and economic burden are important issues for people with sickle cell disease (SCD) owing to better survival due to medical advances. Preference-based or utility information is necessary to make informed economic decisions on treatment and alternative therapies. This study aimed to assess preference-based measures of HRQL in sickle cell patients.

Methods and findings

Data were collected from two SCD outpatient clinics in Ibadan, Nigeria. A standard algorithm was used to derive utility scores, and measure SF-6D from the SF-36. A multivariate regression model was used to assess predictors and their impact. A combination of socio-demographic, bio-physiological and psychosocial variables predicted utility score in people with SCD.

SUBMITTER: Ojelabi AO 

PROVIDER: S-EPMC6860997 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature