The Second Receptor for C5a, C5aR2, Is Detrimental to Mice during Systemic Infection with Listeria monocytogenes.

ABSTRACT: Infection with Listeria monocytogenes is acquired through ingestion of contaminated foods and may lead to systemic infection and possible death, with an overall 20% mortality rate. Our previous work using C5aR1^-/- mice and C3aR^-/- mice demonstrated that C5aR1 and C3aR both play powerful anti-inflammatory and prosurvival roles during systemic infection with L. monocytogenes In our current study, we have examined the role of the third anaphylatoxin receptor, C5aR2, in the host immune response to systemic L. monocytogenes infection. C5aR2^-/- mice had significantly lower bacterial burdens in the spleens and livers on both day 1 and 3 postinfection compared with C5aR2^+/+ mice. The decreased bacterial burdens in the C5aR2^-/-</

SUBMITTER: Mueller-Ortiz SL 

PROVIDER: S-EPMC6861014 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature