A Sulfonamide Sialoside Analogue for Targeting Siglec-8 and -F on Immune Cells.

ABSTRACT: The Siglec family of cell surface receptors have emerged as attractive targets for cell-directed therapies due to their restricted expression on immune cells, endocytic properties, and ability to modulate receptor signaling. Human Siglec-8, for instance, has been identified as a therapeutic target for the treatment of eosinophil and mast cell disorders. A promising strategy to target Siglecs involves the use of liposomal nanoparticles with a multivalent display of Siglec ligands. A key challenge for this approach is the identification of a high affinity ligand for the target Siglec. Here, we report the development of a ligand of Siglec-8 and its closest murine functional orthologue Siglec-F that is capable of targeting liposomes to cells expressing Siglec-8 or -F. A glycan microarray libra

SUBMITTER: Nycholat CM 

PROVIDER: S-EPMC6861165 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature