Stromal-Immune Score-Based Gene Signature: A Prognosis Stratification Tool in Gastric Cancer.

ABSTRACT: Background: A growing amount of evidence has suggested the clinical importance of stromal and immune cells in the gastric cancer microenvironment. However, reliable prognostic signatures based on assessments of stromal and immune components have not been well-established. This study aimed to develop a stromal-immune score-based gene signature in gastric cancer. Methods: Stromal and immune scores were estimated from transcriptomic profiles of a gastric cancer cohort from TCGA using the ESTIMATE algorithm. A robust partial likelihood-based Cox proportional hazard regression model was applied to select prognostic genes and to construct a stromal-immune score-based gene signature. Two independent datasets from GEO were used for external validation. Results: Favorable overa

SUBMITTER: Wang H 

PROVIDER: S-EPMC6861210 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature