A regulatory variant of CHRM3 is associated with cannabis-induced hallucinations in European Americans.

ABSTRACT: Cannabis, the most widely used illicit drug, can induce hallucinations. Our understanding of the biology of cannabis-induced hallucinations (Ca-HL) is limited. We used the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) to identify cannabis-induced hallucinations (Ca-HL) among long-term cannabis users (used cannabis ≥1 year and ≥100 times). A genome-wide association study (GWAS) was conducted by analyzing European Americans (EAs) and African Americans (AAs) in Yale-Penn 1 and 2 cohorts individually, then meta-analyzing the two cohorts within population. In the meta-analysis of Yale-Penn EAs (n = 1917), one genome-wide significant (GWS) signal emerged at the CHRM3 locus, represented by rs115455482 (P = 1.66 × 10^-10), rs74722579 (P = 2.81 × 10^-9),

SUBMITTER: Cheng Z 

PROVIDER: S-EPMC6861240 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature