Circulating metabolites in progression to islet autoimmunity and type 1 diabetes.

ABSTRACT:

Aims/hypothesis

Metabolic dysregulation may precede the onset of type 1 diabetes. However, these metabolic disturbances and their specific role in disease initiation remain poorly understood. In this study, we examined whether children who progress to type 1 diabetes have a circulatory polar metabolite profile distinct from that of children who later progress to islet autoimmunity but not type 1 diabetes and a matched control group.

Methods

We analysed polar metabolites from 415 longitudinal plasma samples in a prospective cohort of children in three study groups: those who progressed to type 1 diabetes; those who seroconverted to one islet autoantibody but not to type 1 diabetes; and an antibody-negative control group. Metabolites were measured using two-dimensional GC high

SUBMITTER: Lamichhane S 

PROVIDER: S-EPMC6861356 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature