High-Sensitive Troponin T, Natriuretic Peptide, and Cognitive Change.

ABSTRACT:

Objectives

Cardiac troponin T, measured using a high-sensitive assay (hs-cTnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are associated with increased stroke risk and perhaps with cognitive decline. However, few well-designed prospective studies with extended follow-up have been conducted. We aimed to estimate the association of hs-cTnT and NT-proBNP with 15-year cognitive change in the Atherosclerosis Risk in Communities (ARIC) study.

Design

Prospective cohort study.

Setting

Four US communities.

Participants

A total of 9114 and 9108 participants from the Atherosclerosis Risk in Communities study for analyses of hs-cTnT and NT-proBNP, respectively.

Measurements

We examined association of hs-cTnT and NT-proBNP with 15-year change (1996-19

SUBMITTER: Pokharel Y 

PROVIDER: S-EPMC6861618 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature