Analysis of lncRNA-mRNA expression pattern in male textile workers with noise-induced hearing loss.

ABSTRACT:

Background

Extracellular long non-coding RNA (lncRNA) has attracted increasing attention as a potential biomarker to indicate disease status and physiological process. It plays a unique role in pathogenesis, and may be a new potential biomarker, especially for chronic hearing loss. Early screening of NIHL susceptible population is of great significance in reducing the incidence of NIHL.

Methods

The expression profiles of lncRNAs and mRNAs in serum of noise-induced hearing loss (NIHL) and exposure groups were detected by microarray technique in serum. The differentially expressed mRNAs was analyzed by GO and KEGG to identify related biological functions and signaling pathways. The top up-regulated and down regulated lncRNAs were identified by qRT-PCR.

Results

A total o

SUBMITTER: Wang N 

PROVIDER: S-EPMC6861780 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature