Genome-wide profiling of prognosis-related alternative splicing signatures in sarcoma.

ABSTRACT:

Background

Sarcomas (SARCs) are rare malignant tumors with poor prognosis. Increasing evidence has suggested that aberrant alternative splicing (AS) is strongly associated with tumor initiation and progression. We considered whether survival-related AS events might serve as prognosis predictors and underlying targeted molecules in SARC treatment.

Methods

RNA-Seq data of the SARC cohort were downloaded from The Cancer Genome Atlas (TCGA) database. Survival-related AS events were selected by univariate and multivariate Cox regression analyses. Metascape was used for constructing a gene interaction network and performing functional enrichment analysis. Then, prognosis predictors were established based on statistically significant survival-related AS events and evaluated by rece

SUBMITTER: Hong W 

PROVIDER: S-EPMC6861818 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature