Which Low-Abundance Proteins are Present in the Human Milieu of Gamete/Embryo Maternal Interaction?

ABSTRACT: The improvement of the embryo culture media is of high relevance due to its influence on successful implantation rates, pregnancy, neonatal outcomes, and potential effects in adult life. The ideal conditions for embryo development are those naturally occurring in the female reproductive tract, i.e., the oviductal and uterine fluids. To shed light on the differences between chemical and natural media, we performed the first comparative study of the low abundance proteins in plasma, uterine, and oviductal fluid collected, simultaneously, from healthy and fertile women that underwent a salpingectomy. The rationale for this design derives from the fact that high-abundant proteins in these fluids are usually those coming from blood serum and frequently mask the detection of low abundant protein

SUBMITTER: Canha-Gouveia A 

PROVIDER: S-EPMC6861935 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature