Evaluation of Targeted Delivery to the Brain Using Magnetic Immunoliposomes and Magnetic Force.

ABSTRACT: Magnetic nanoparticles have great prospects for drug delivery purposes, as they can be designed with various surface coatings and conjugated with drugs and targeting moieties. They also have a unique potential for precise delivery when guided by magnetic force. The blood-brain barrier (BBB) denotes the interface between the blood and brain parenchyma and hinders the majority of drugs from entering the brain. Red fluorescent magnetic nanoparticles were encapsulated in liposomes and conjugated to antibodies targeting the rat transferrin receptor (OX26) to form magnetic immunoliposomes. These magnetic immunoliposomes enhanced the uptake by rat brain capillary endothelial cells (BCECs) in vitro. In situ brain perfusion in young rats high in the endogenous expression of transferrin receptors by

SUBMITTER: Thomsen LB 

PROVIDER: S-EPMC6861967 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature