Independent and Combined Effects of Telomere Shortening and mtDNA⁴⁹⁷⁷ Deletion on Long-term Outcomes of Patients with Coronary Artery Disease.

ABSTRACT: Aging is one of the main risk factors for cardiovascular disease, resulting in a progressive organ and cell decline. This study evaluated a possible joint impact of two emerging hallmarks of aging, leucocyte telomere length (LTL) and common mitochondrial DNA deletion (mtDNA⁴⁹⁷⁷), on major adverse cardiovascular events (MACEs) and all-cause mortality in patients with coronary artery disease (CAD). We studied 770 patients (673 males, 64.8 ± 8.3 years) with known or suspected stable CAD. LTL and mtDNA⁴⁹⁷⁷ deletion were assessed in peripheral blood using qRT-PCR. During a median follow-up of 5.4 ± 1.2 years, MACEs were 140 while 86 deaths were recorded. After adjustments for confounding risk factors, short LTLs and high mtDNA⁴⁹⁷⁷ deletion levels acted independe

SUBMITTER: Vecoli C 

PROVIDER: S-EPMC6862167 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature