Lack of Delta-Sarcoglycan (Sgcd) Results in Retinal Degeneration.

ABSTRACT: Age-related macular degeneration (AMD) is the leading cause of central vision loss and severe blindness among the elderly population. Recently, we reported on the association of the SGCD gene (encoding for δ-sarcoglycan) polymorphisms with AMD. However, the functional consequence of Sgcd alterations in retinal degeneration is not known. Herein, we characterized changes in the retina of the Sgcd knocked-out mouse (KO, Sgcd^-/-). At baseline, we analyzed the retina structure of three-month-old wild-type (WT, Sgcd^+/+) and Sgcd^-/- mice by hematoxylin and eosin (H&E) staining, assessed the Sgcd-protein complex (α-, β-, γ-, and ε-sarcoglycan, and sarcospan) by immunofluorescence (IF) and Western blot (WB), and performed electroretinogra

SUBMITTER: Perez-Ortiz AC 

PROVIDER: S-EPMC6862322 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature