Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors.

ABSTRACT: Minor structural modifications-sometimes single atom changes-can have a dramatic impact on the properties of compounds. This is illustrated here on structures related to known mTOR inhibitor Sapanisertib. Subtle changes in the hinge binder lead to strikingly different overall profiles with changes in physical properties, metabolism, and kinase selectivity.

SUBMITTER: Ouvry G 

PROVIDER: S-EPMC6862343 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature