Project description:Multiple sclerosis (MS) is an inflammatory disease of the central nervous system characterised by myelin loss and progressive neurodegeneration. To better understand MS lesion initiation and progression, we generated spatial gene activity maps of white (WM) and grey matter (GM) MS lesions. In different MS lesion types, we detected novel transcriptional domains, including an identifiable rim around active WM lesions. These active lesion rims were characterised by changes in astrocytic, oligodendrocytic, and microglial gene activity. Furthermore, we identified three novel WM lesion trajectories, predicting how normal appearing WM could progress into WM lesions, with lesion rims, active lesion cores, and mixed active/inactive lesion cores as potential outcomes. Our findings offer new insights into MS lesion progression, and the dynamic molecular and cellular processes that underlie MS.

2024-08-05 | GSE208747 | GEO

ATP release into ADPKD cysts via pannexin-1/P2X7 channels decreases ENaC activity.

Project description: Not available

| S-EPMC6475605 | biostudies-literature

Chronic lesion activity and disability progression in secondary progressive multiple sclerosis.

Project description: Not available

| S-EPMC9185385 | biostudies-literature

A multiple sclerosis disease progression measure based on cumulative disability.

Project description: Not available

| S-EPMC8521354 | biostudies-literature

Progression independent of relapse activity in relapsing multiple sclerosis: impact and relationship with secondary progression.

Project description: Not available