Bioinformatic identification of key candidate genes and pathways in axon regeneration after spinal cord injury in zebrafish.

ABSTRACT: Zebrafish and human genomes are highly homologous; however, despite this genomic similarity, adult zebrafish can achieve neuronal proliferation, regeneration and functional restoration within 6-8 weeks after spinal cord injury, whereas humans cannot. To analyze differentially expressed zebrafish genes between axon-regenerated neurons and axon-non-regenerated neurons after spinal cord injury, and to explore the key genes and pathways of axonal regeneration after spinal cord injury, microarray GSE56842 was analyzed using the online tool, GEO2R, in the Gene Expression Omnibus database. Gene ontology and protein-protein interaction networks were used to analyze the identified differentially expressed genes. Finally, we screened for genes and pathways that may play a role in spinal cord injury

SUBMITTER: Li JH 

PROVIDER: S-EPMC6862403 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature