Therapeutic Properties of Mesenchymal Stem Cell on Organ Ischemia-Reperfusion Injury.

ABSTRACT: The shortage of donor organs is a major global concern. Organ failure requires the transplantation of functional organs. Donor's organs are preserved for variable periods of warm and cold ischemia time, which requires placing them into a preservation device. Ischemia and reperfusion damage the organs, due to the lack of oxygen during the ischemia step, as well as the oxidative stress during the reperfusion step. Different methodologies are developed to prevent or to diminish the level of injuries. Preservation solutions were first developed to maximize cold static preservation, which includes the addition of several chemical compounds. The next chapter of organ preservation comes with the perfusion machine, where mechanical devices provide continuous flow and oxygenation ex vivo to the org

SUBMITTER: Oliva J 

PROVIDER: S-EPMC6862572 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature