Fusion Transcripts of Adjacent Genes: New Insights into the World of Human Complex Transcripts in Cancer.

ABSTRACT: The awareness of genome complexity brought a radical approach to the study of transcriptome, opening eyes to single RNAs generated from two or more adjacent genes according to the present consensus. This kind of transcript was thought to originate only from chromosomal rearrangements, but the discovery of readthrough transcription opens the doors to a new world of fusion RNAs. In the last years many possible intergenic cis-splicing mechanisms have been proposed, unveiling the origins of transcripts that contain some exons of both the upstream and downstream genes. In some cases, alternative mechanisms, such as trans-splicing and transcriptional slippage, have been proposed. Five databases, containing validated and predicted Fusion Transcripts of Adjacent Genes (FuTAGs), are available for t

SUBMITTER: Barresi V 

PROVIDER: S-EPMC6862657 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature