A five-long non-coding RNA signature with the ability to predict overall survival of patients with lung adenocarcinoma.

ABSTRACT: An increasing number of studies have indicated that the abnormal expression of certain long non-coding RNAs (lncRNAs) is linked to the overall survival (OS) of patients with lung adenocarcinoma (LUAD). The aim of the present study was to establish an lncRNA signature to predict the survival of patients with LUAD. The gene expression profiles and associated clinical information of patients with LUAD were downloaded from The Cancer Genome Atlas database. The cohort was randomly sub-divided into training and verification cohorts. Univariate Cox regression analysis was performed on differentially expressed lncRNAs in the training cohort to select candidate lncRNAs closely associated with survival. Next, a risk score (RS) model consisting of 5 lncRNAs was established by multivariate Cox regress

SUBMITTER: Zeng L 

PROVIDER: S-EPMC6862666 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature