Clinical significance of stromal ER and PR expression in periampullary adenocarcinoma.

ABSTRACT:

Background

Tamoxifen treatment has previously been reported to confer life-prolonging effects in patients with advanced pancreatic cancer, and most evidently so in women. None of these trials did however include biomarkers, and the relevance of female hormone signaling in pancreatic or other periampullary adenocarcinoma remains largely unexplored. The aim of this study was to examine the extent and potential clinical significance of estrogen receptor-α (ER) and progesterone receptor (PR) expression in pancreatic and other periampullary cancers.

Methods

ER and PR expression was examined using immunohistochemistry on tissue microarrays with primary tumors from a retrospective consecutive cohort of 175 patients with resected periampullary adenocarcinoma, with long-term clinical

SUBMITTER: Andersson G 

PROVIDER: S-EPMC6862740 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature