Deletion of the fungus specific protein phosphatase Z1 exaggerates the oxidative stress response in Candida albicans.

ABSTRACT:

Background

Candida albicans is an opportunistic pathogen which is responsible for widespread nosocomial infections. It encompasses a fungus specific serine/threonine protein phosphatase gene, CaPPZ1 that is involved in cation transport, cell wall integrity, oxidative stress response, morphological transition, and virulence according to the phenotypes of the cappz1 deletion mutant.

Results

We demonstrated that a short-term treatment with a sublethal concentration of tert-butyl hydroperoxide suppressed the growth of the fungal cells without affecting their viability, both in the cappz1 mutant and in the genetically matching QMY23 control strains. To reveal the gene expression changes behind the above observations we carried out a global transcriptome analysis. We used a pilot

SUBMITTER: Szabo K 

PROVIDER: S-EPMC6862791 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature