LncRNA SNHG8 is identified as a key regulator of acute myocardial infarction by RNA-seq analysis.

ABSTRACT:

Background

Long noncoding RNAs (lncRNAs) are involved in numerous physiological functions. However, their mechanisms in acute myocardial infarction (AMI) are not well understood.

Methods

We performed an RNA-seq analysis to explore the molecular mechanism of AMI by constructing a lncRNA-miRNA-mRNA axis based on the ceRNA hypothesis. The target microRNA data were used to design a global AMI triple network. Thereafter, a functional enrichment analysis and clustering topological analyses were conducted by using the triple network. The expression of lncRNA SNHG8, SOCS3 and ICAM1 was measured by qRT-PCR. The prognostic values of lncRNA SNHG8, SOCS3 and ICAM1 were evaluated using a receiver operating characteristic (ROC) curve.

Results

An AMI lncRNA-miRNA-mRNA network was co

SUBMITTER: Zhuo LA 

PROVIDER: S-EPMC6862811 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature