Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma.

ABSTRACT:

Background

High grade serous ovarian carcinoma (HGSOC) is the most common subtype of epithelial ovarian cancers (EOC) with poor prognosis. In most cases EOC is widely disseminated at the time of diagnosis. Despite the optimal cytoreductive surgery and chemotherapy most patients develop chemoresistance, and the 5-year overall survival being only 25-35%.

Methods

Here we analyzed the gene expression profiles of 10 primary HGSOC tumors and 10 related omental metastases using RNA sequencing and identified 100 differentially expressed genes.

Results

The differentially expressed genes were associated with decreased embryogenesis and vasculogenesis and increased cellular proliferation and organismal death. Top upstream regulators responsible for this gene signature were NR5A1

SUBMITTER: Sallinen H 

PROVIDER: S-EPMC6862850 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature