Metabolic signature of healthy lifestyle and its relation with risk of hepatocellular carcinoma in a large European cohort.

ABSTRACT:

Background

Studies using metabolomic data have identified metabolites from several compound classes that are associated with disease-related lifestyle factors.

Objective

In this study, we identified metabolic signatures reflecting lifestyle patterns and related them to the risk of hepatocellular carcinoma (HCC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

Design

Within a nested case-control study of 147 incident HCC cases and 147 matched controls, partial least squares (PLS) analysis related 7 modified healthy lifestyle index (HLI) variables (diet, BMI, physical activity, lifetime alcohol, smoking, diabetes, and hepatitis) to 132 targeted serum-measured metabolites and a liver function score. The association between the resulting

SUBMITTER: Assi N 

PROVIDER: S-EPMC6862938 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature