Appropriate empirical antibiotic therapy and mortality: Conflicting data explained by residual confounding.

ABSTRACT: OBJECTIVE:Clinical practice universally assumes that appropriate empirical antibiotic therapy improves survival in patients with bloodstream infection. However, this is not generally supported by previous studies. We examined the association between appropriate therapy and 30-day mortality, while minimizing bias due to confounding by indication. METHODS:We conducted a retrospective cohort study between 2012 and 2017 at a tertiary university hospital in the Netherlands. Adult patients with bloodstream infection attending the emergency department were included. Based on in vitro susceptibility, antibiotic therapy was scored as appropriate or inappropriate. Primary outcome was 30-day mortality. To control for confounding, we performed conventional multivariable logistic regression and propens

SUBMITTER: Schuttevaer R 

PROVIDER: S-EPMC6863559 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature