Correlations between secondary structure- and protein-protein interface-mimicry: the interface mimicry hypothesis.

ABSTRACT: An active segment of the research community designing small molecules ("minimalist mimics" of peptide fragments) to interfere with protein-protein interactions have based their studies on an implicit hypothesis. Here we refer to this as the Secondary Structure Hypothesis, that might be defined as, "If a small molecule can orient amino acid side-chains in directions that resemble side-chains of the parent secondary structure at the interface, then that small molecule is a candidate to perturb the protein-protein interaction". Rigorous tests of this hypothesis require co-crystallization of minimalist mimics with protein receptors, and comparison of the bound conformations with the interface secondary structures they were designed to resemble. Unfortunately, to the best of our knowledge, ther

SUBMITTER: Taechalertpaisarn J 

PROVIDER: S-EPMC6863600 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature