Resveratrol modulates the gut microbiota to prevent murine colitis development through induction of Tregs and suppression of Th17 cells.

ABSTRACT: Inflammatory diseases of the gastrointestinal tract are often associated with microbial dysbiosis. Thus, dietary interactions with intestinal microbiota, to maintain homeostasis, play a crucial role in regulation of clinical disorders such as colitis. In the current study, we investigated if resveratrol, a polyphenol found in a variety of foods and beverages, would reverse microbial dysbiosis induced during colitis. Administration of resveratrol attenuated colonic inflammation and clinical symptoms in the murine model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis. Resveratrol treatment in mice with colitis led to an increase in CD4⁺ FOXP3⁺ and CD4⁺ IL-10⁺ T cells, and a decrease in CD4⁺ IFN-γ⁺ and CD4⁺

SUBMITTER: Alrafas HR 

PROVIDER: S-EPMC6863607 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature