Length regulation of multiple flagella that self-assemble from a shared pool of components.

ABSTRACT: The single-celled green algae Chlamydomonas reinhardtii with its two flagella-microtubule-based structures of equal and constant lengths-is the canonical model organism for studying size control of organelles. Experiments have identified motor-driven transport of tubulin to the flagella tips as a key component of their length control. Here we consider a class of models whose key assumption is that proteins responsible for the intraflagellar transport (IFT) of tubulin are present in limiting amounts. We show that the limiting-pool assumption is insufficient to describe the results of severing experiments, in which a flagellum is regenerated after it has been severed. Next, we consider an extension of the limiting-pool model that incorporates proteins that depolymerize microtubules. W

SUBMITTER: Fai TG 

PROVIDER: S-EPMC6863624 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature