Epigenetic Regulation in the Pathogenesis of Sjogren Syndrome and Rheumatoid Arthritis.

ABSTRACT: Autoimmune rheumatic diseases, such as Sjögren syndrome (SS) and rheumatoid arthritis (RA), are characterized by chronic inflammation and autoimmunity, which cause joint tissue damage and destruction by triggering reduced mobility and debilitation in patients with these diseases. Initiation and maintenance of chronic inflammatory stages account for several mechanisms that involve immune cells as key players and the interaction of the immune cells with other tissues. Indeed, the overlapping of certain clinical and serologic manifestations between SS and RA may indicate that numerous immunologic-related mechanisms are involved in the physiopathology of both these diseases. It is widely accepted that epigenetic pathways play an essential role in the development and function of the immune syst

SUBMITTER: Ibanez-Cabellos JS 

PROVIDER: S-EPMC6863924 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature